Simulation in vitro of pulsatile vascular hemodynamics using a CAD/CAM-designed cam disc and roller follower

An in vitro perfusion circuit is described that is capable of stimulating pulsatile peripheral vascular hemodynamics. A novel feature of its design is the incorporation of a computer-aided design and manufacture disc cam and roller follower for delivery of pulsatile hemodynamics. To date approximately 75 canine carotids have been perfused for periods of 2-24 h. The delivery of quantifiable hemodynamics in vitro via the rotation of a cam and roller follower has been found to be highly reliable on a cycle-to-cycle basis.