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HOXC Cluster Antisense RNA 3, a Novel Long Non-Coding RNA as an Oncological Biomarker and Therapeutic Target in Human

Yunhe Xie1,2, Jiarong Ye3, Hongliang Luo1

  • 1Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330008, People's Republic of China.

Oncotargets and Therapy
|October 30, 2023
PubMed

Insights

HOXC-AS3, a long noncoding RNA (lncRNA), is frequently altered in cancers and impacts tumor progression. This review highlights its potential as a diagnostic and prognostic biomarker for malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in cancer.
  • HOXC cluster antisense RNA 3 (HOXC-AS3) is a novel lncRNA with aberrant expression in various cancer types.
  • HOXC-AS3's expression correlates with clinicopathological features, indicating clinical relevance.

Purpose of the Study:

  • To review and analyze the expression and clinical significance of HOXC-AS3 in malignancies.
  • To provide an update on the functions and regulatory mechanisms of HOXC-AS3 in cancer pathogenesis.
  • To underscore HOXC-AS3's potential as a diagnostic, prognostic, and therapeutic target.

Main Methods:

  • Literature review and comprehensive analysis of existing studies on HOXC-AS3.
  • Synthesis of data regarding HOXC-AS3 expression patterns in different cancers.
  • Compilation of evidence on HOXC-AS3's functional roles and regulatory mechanisms in tumor progression.

Main Results:

  • HOXC-AS3 exhibits aberrant expression across multiple cancer types.
  • HOXC-AS3 influences key cancer processes including proliferation, apoptosis, migration, invasion, EMT, autophagy, and senescence.
  • HOXC-AS3 is linked to tumor growth and metastasis.

Conclusions:

  • HOXC-AS3 is a promising biomarker for cancer diagnosis and prognosis.
  • HOXC-AS3 plays multifaceted roles in cancer development and progression.
  • HOXC-AS3 represents a potential therapeutic target for clinical applications in oncology.
Keywords:
HOXC-AS3biological markerlong non-coding RNAmalignant neoplasmsneoplastic processes

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