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Research progress on moyamoya disease combined with thyroid diseases

Guibo Zhang1,2, Erheng Liu3, XueYi Tan1,2

  • 1The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

Frontiers in Endocrinology
|October 30, 2023
PubMed

Insights

Moyamoya disease (MMD) and thyroid disorders may be linked. This review explores potential connections, including immune factors and genetics, to guide MMD treatment.

Area of Science:

  • Neurology
  • Endocrinology
  • Immunology

Background:

  • Moyamoya disease (MMD) involves progressive blockage of brain arteries.
  • Coexistence of MMD and thyroid diseases is increasingly reported, but mechanisms remain unclear.
  • Thyroid diseases include Grave disease, thyrotoxicosis, and autoimmune conditions.

Purpose of the Study:

  • To review existing literature on the relationship between MMD and thyroid diseases.
  • To explore potential pathogenic mechanisms linking MMD and thyroid disorders.
  • To provide insights for treating MMD in patients with coexisting thyroid conditions.

Main Methods:

  • Systematic literature search using keywords: "moyamoya disease", "thyroid", "Grave disease", "thyrotoxicosis", "thyroid autoimmune antibodies".
  • Inclusion of 52 relevant articles from PubMed and Web of Science databases.
  • Review focused on thyroid hormone function, autoimmune antibodies, genetic correlations, and treatment strategies.

Main Results:

  • The review synthesizes current research on the interplay between MMD and thyroid conditions.
  • Potential links involve thyroid hormone's role, autoimmune antibody mechanisms, and shared genetic factors.
  • Treatment considerations for MMD in the context of thyroid disease are discussed.

Conclusions:

  • Further research is needed to elucidate the exact relationship between MMD and thyroid diseases.
  • Understanding these connections may lead to improved diagnostic and therapeutic approaches for MMD.
  • This review serves as a reference for clinicians and researchers investigating MMD with comorbid thyroid conditions.
Keywords:
grave diseasemoyamoya diseasereviewthyroidthyrotoxicosis

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