Related Experiment Video
Updated: Jul 12, 2025
06:54
A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
Published on: June 22, 2022
2.8K
Research progress on moyamoya disease combined with thyroid diseases
Guibo Zhang1,2, Erheng Liu3, XueYi Tan1,2
1The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Frontiers in Endocrinology
|October 30, 2023
Summary
Moyamoya disease (MMD) and thyroid disorders may be linked. This review explores potential connections, including immune factors and genetics, to guide MMD treatment.
Area of Science:
- Neurology
- Endocrinology
- Immunology
Background:
- Moyamoya disease (MMD) involves progressive blockage of brain arteries.
- Coexistence of MMD and thyroid diseases is increasingly reported, but mechanisms remain unclear.
- Thyroid diseases include Grave disease, thyrotoxicosis, and autoimmune conditions.
Purpose of the Study:
- To review existing literature on the relationship between MMD and thyroid diseases.
- To explore potential pathogenic mechanisms linking MMD and thyroid disorders.
- To provide insights for treating MMD in patients with coexisting thyroid conditions.
Main Methods:
- Systematic literature search using keywords: "moyamoya disease", "thyroid", "Grave disease", "thyrotoxicosis", "thyroid autoimmune antibodies".
- Inclusion of 52 relevant articles from PubMed and Web of Science databases.
- Review focused on thyroid hormone function, autoimmune antibodies, genetic correlations, and treatment strategies.
Main Results:
- The review synthesizes current research on the interplay between MMD and thyroid conditions.
- Potential links involve thyroid hormone's role, autoimmune antibody mechanisms, and shared genetic factors.
- Treatment considerations for MMD in the context of thyroid disease are discussed.
Conclusions:
- Further research is needed to elucidate the exact relationship between MMD and thyroid diseases.
- Understanding these connections may lead to improved diagnostic and therapeutic approaches for MMD.
- This review serves as a reference for clinicians and researchers investigating MMD with comorbid thyroid conditions.
Related Concept Videos
01:20Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
01:23The Thyroid Gland
3.9K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.9K
01:26Coronary Artery Disease II: Pathophysiology
12
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
12
01:26Atherosclerosis III: Management
11
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
11
01:18Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
11
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
11