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Related Experiment Videos

Local myocardial and global ventricular function compared during positive inotropic medication.

P P Lunkenheimer, A Lunkenheimer, W F Whimster

    Basic Research in Cardiology
    |January 1, 1986
    PubMed
    Summary

    Cardiotonic drugs like Amrinon affect heart muscle force generation. Direct measurement shows Amrinon is a potent positive inotropic drug, despite altering force patterns.

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    Area of Science:

    • Cardiovascular pharmacology
    • Cardiac mechanics
    • Myocardial force generation

    Background:

    • Assessing cardiotonic drugs is complex due to myocardial meshwork force generation.
    • Distinguishing between "afterloaded" and "unloading" force types is crucial for understanding drug effects.
    • These force types correlate with specific myocardial fiber orientations.

    Purpose of the Study:

    • To investigate the pharmacological effects of Amrinon on myocardial force generation.
    • To determine if Amrinon's inotropic effects can be accurately measured using traditional indices.
    • To establish a direct method for assessing Amrinon's efficacy in the heart.

    Main Methods:

    • Utilized multifocal local force and distance measurements to analyze myocardial mechanics.

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  • Differentiated between "afterloaded" and "unloading" force types based on transient behavior.
  • Employed direct intracoronary drug injection with segmental force and distance monitoring.

    • Main Results:

    • Amrinon reduces both pre-load and afterload, causing ventricular shrinkage.
    • Ventricular shrinkage alters intramural force transmission, rendering left ventricular pressure-derived indices inapplicable.
    • Direct measurements confirmed Amrinon as a potent positive inotropic agent.

    Conclusions:

    • Traditional contractility indices are insufficient for evaluating drugs like Amrinon due to altered force transmission.
    • Direct measurement of myocardial force and distance is a reliable method for assessing cardiotonic drug efficacy.
    • Amrinon demonstrates significant positive inotropic effects when directly measured within the myocardium.