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Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

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First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report.

Aryeh Babkoff^1,2, Yael Berner-Wygoda^1,2, Judith Diment^2,3

¹Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Case Reports in Oncology

|October 30, 2023

Summary

This summary is machine-generated.

A rare CIC-FOXO4 translocation sarcoma, a subtype of small round cell sarcoma, was identified. This report details the pathological, clinical, and molecular characteristics of this exceedingly uncommon tumor.

Area of Science:

Oncology
Pathology
Genetics

Background:

Small round cell sarcomas are undifferentiated malignancies of bone and soft tissue.

Keywords:

CIC-FOXO4 translocation Small round blue cell sarcoma Transcriptome

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The World Health Organization now recognizes CIC-rearranged sarcoma as a distinct subtype.

CIC-FOXO4 translocation represents an extremely rare fusion within this group, with only four prior reports.