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Localized Multifocal Retroperitoneal Ganglioneuroma with an Infiltrative Appearance on Imaging: A Case Report
Joseph M Rich1, Vinay A Duddalwar2,3, Manju Aron4
1MD/PhD Program, USC-Caltech MD/PhD Program, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Case Reports in Oncology
|October 30, 2023
Summary
Multifocal ganglioneuromas are rare tumors. This case highlights a retroperitoneal multifocal ganglioneuroma with fatty infiltration, emphasizing its distinct radiological and pathological features.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Multifocal ganglioneuromas, rare neuroepithelial tumors, present diagnostic challenges due to their infrequent occurrence and subtle symptoms.
- A subset of ganglioneuromas exhibit a fatty appearance, further complicating their identification.
Observation:
- A case of multifocal retroperitoneal ganglioneuroma with an infiltrative computed tomography (CT) appearance is presented.
- The tumor showed slow growth over 18 months and was associated with abdominal and flank pain.
- Post-surgical imaging revealed nodularity and infiltration, clarifying its retroperitoneal location adjacent to the adrenal gland.
Findings:
- Histological examination confirmed benign Schwann cells and ganglion cells without atypia, increased cellularity, mitosis, or necrosis.
- The imaging findings were crucial in differentiating this multifocal ganglioneuroma with fatty infiltration from other lipomatous tumors.
Implications:
- This case underscores the importance of considering multifocal ganglioneuroma with fatty infiltration in the differential diagnosis of retroperitoneal fatty masses.
- Distinguishing this entity from lipomatous ganglioneuroma based on radiological and histopathological features is critical for accurate diagnosis and management.
