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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Visible-light-mediated synthesis of oxime esters via multicomponent reactions of aldehydes, aryl amines, and
Anh Thu Nguyen1, Hee-Kwon Kim1,2
1Department of Nuclear Medicine, Jeonbuk National University Medical School and Hospital Jeonju 54907 Republic of Korea hkkim717@jbnu.ac.kr.
Abstract:
Oxime esters are useful scaffolds in many organic chemistry transformations. Herein, a novel visible-light-mediated three-component reaction for synthesis of oxime esters is reported. Aldehydes, aniline, and N-hydroxyphthalimide (NHPI) esters were used as substrates in this three-component reaction, and eosin Y was used as a crucial photocatalyst for the reaction. Wide ranges of aldehydes and NHPI esters were well tolerated in this reaction method, generating various oxime esters with high efficiency under mild reaction conditions. This visible-light-mediated methodology will be a promising approach to synthesize useful oxime esters in a single step.
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