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Related Concept Videos

Sample Handling01:02

Sample Handling

105
Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
Samples should be transported carefully from collection points to the laboratory. They should be properly sealed and clearly labeled to prevent cross-contamination. To preserve the sample integrity, optimal temperature conditions during transport are essential. This could involve using...
105
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

209
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
209
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

136
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
136

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Updated: Jul 12, 2025

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods
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Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations.

Nuning Vita Hidayati1,2, Laurence Asia3, Stephanie Lebarillier3

  • 1Fisheries and Marine Sciences Faculty, Jenderal Soedirman University, Kampus Karangwangkal, Jl. Dr. Suparno, Purwokerto 53123, Indonesia.

Journal of Analytical Methods in Chemistry
|October 30, 2023
PubMed
Summary

Properly storing pharmaceutical compounds in solid-phase extraction cartridges is crucial for environmental analysis. Storing at -18°C preserves samples for six months, while room temperature is suitable for three days.

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Area of Science:

  • Environmental Chemistry
  • Analytical Chemistry

Background:

  • Accurate detection of pharmaceutical compounds in environmental water samples is critical.
  • Effective sample preservation techniques are needed for reliable quantitative analysis.

Purpose of the Study:

  • To investigate the stability of key pharmaceutical compounds after preconcentration using solid-phase extraction (SPE).
  • To establish optimal storage conditions for environmental water samples containing pharmaceuticals.

Main Methods:

  • Stability assessment of 17α-ethynylestradiol (EE2), acetaminophen (ACM), oxytetracycline (OTC), sulfamethoxazole (SMX), and trimethoprim (TMP).
  • Samples were preconcentrated in SPE cartridges and stored under various time and temperature conditions (4°C, -18°C, room temperature).

Main Results:

  • Four pharmaceutical compounds showed stability for one month at 4°C and six months at -18°C in darkness.
  • All five tested compounds (ACM, TMP, OTC, EE2, SMX) remained stable for three days at room temperature.
  • Storage in SPE cartridges at -18°C proved effective for long-term preservation.

Conclusions:

  • Developed guidelines for handling and storing pharmaceutical compounds preconcentrated from aqueous environmental samples.
  • Demonstrated the feasibility of using SPE cartridges for sample preservation under specific temperature and time constraints.