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Author Spotlight: Advancements in Understanding and Combatting Shigella Infections
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Trends in antimicrobial resistance of Shigella species in Peru, 2011-2020

Willi Quino1, Gustavo Bellido1, Diana Flores-León1,2

  • 1Laboratorio de Referencia Nacional de Bacteriología Clínica, Instituto Nacional de Salud, Lima, Perú.

Jac-Antimicrobial Resistance
|October 30, 2023
PubMed
Abstract

Insights

Antimicrobial resistance in Shigella species in Peru is high, particularly for trimethoprim/sulfamethoxazole and tetracycline. Resistance to fluoroquinolones like ciprofloxacin is increasing, posing a threat to treating Shigella infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Shigella species are a major cause of bacterial dysentery worldwide.
  • Antimicrobial resistance in Shigella poses a significant public health threat, complicating treatment and increasing morbidity and mortality.
  • Understanding the trends of antimicrobial resistance is crucial for effective treatment strategies and disease control.

Purpose of the Study:

  • To determine the frequency of antimicrobial resistance rates in Shigella species.
  • To analyze the spatial-temporal distribution of Shigella species over a 10-year period in Peru.
  • To identify trends in antimicrobial resistance patterns for effective public health interventions.

Main Methods:

  • A cross-sectional descriptive study analyzed 1668 Shigella strains from 2011-2020.
  • Strains were confirmed using conventional tests and serotyped.
  • Antimicrobial susceptibility testing was performed using the Kirby-Bauer method.

Main Results:

  • Shigella sonnei (49.2%) was the most frequent species, followed by S. flexneri (42.2%).
  • High resistance rates were observed for trimethoprim/sulfamethoxazole (91.0%), tetracycline (88.4%), and ampicillin (73.9%).
  • A significant increase in antimicrobial resistance to fluoroquinolones, including ciprofloxacin, was noted from 2017 to 2020.

Conclusions:

  • Shigella sonnei is the predominant species, exhibiting high resistance to trimethoprim/sulfamethoxazole.
  • The growing resistance to fluoroquinolones and other commonly used antibiotics is alarming.
  • Urgent interventions are needed to combat rising antimicrobial resistance and manage Shigella infections effectively.

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