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Published on: April 14, 2023
Three-year follow-up results of two children born from a transplanted uterus
Jan Janota1, Ekaterina Orlova1, Marta Novackova2
1Department of Neonatology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Insights
Children born after uterine transplantation show normal growth and neurodevelopment up to age 3. This study tracked two such children, confirming promising outcomes despite premature birth, a known risk of uterus transplantation.
Area of Science:
- Reproductive Medicine
- Pediatric Development
- Transplant Surgery
Background:
- Uterus transplantation offers a novel treatment for uterine factor infertility.
- Pregnancy following uterus transplantation presents unique challenges, including the risk of preterm birth.
Purpose of the Study:
- To assess the 3-year follow-up outcomes of two children born to mothers with a transplanted uterus.
- To evaluate the neurodevelopmental status of these children.
Main Methods:
- Observational study of pregnancy and neonatal course.
- Longitudinal follow-up of growth trajectory over 3 years.
- Neurodevelopmental assessment using the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III).
Main Results:
- Both children were born prematurely via cesarean section to mothers with Mayer-Rokitansky-Küster-Hauser syndrome and a transplanted uterus.
- Children exhibited normal growth and had an uneventful postnatal course.
- Bayley-III scores at ages 2 and 3 years were within normal ranges, indicating typical neurodevelopment.
Conclusions:
- Pregnancy after uterus transplantation, while associated with preterm delivery risk, can result in healthy offspring.
- This study reports the first neurodevelopmental outcomes in children born after uterus transplantation, showing promising results.
- Further research with larger cohorts is needed to confirm these findings for uterine factor infertility treatment.
Aims:
To evaluate the 3-year follow-up results of two children delivered at our institution in 2019 from mothers with a transplanted uterus.
Methods:
Observational data on pregnancy outcomes, neonatal course, and growth trajectory in two children born to mothers after uterus transplantation, including 3-year follow-up and neurodevelopmental status assessed using the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III).
Results:
Both children were born prematurely via uneventful caesarean sections, to mothers with Mayer-Rokitansky-Küster-Hauser syndrome and a transplanted uterus. An acute caesarean section was performed in one mother because of the onset of regular uterine contractions at 34 weeks and 6 days of pregnancy; in the other mother, an elective caesarean section was performed at 36 weeks and 2 days of gestation. The children were born healthy with no congenital malformations. They had an uneventful postnatal course and showed a normal growth trajectory during 3 years of follow-up. The Bayley-III neurodevelopmental scores of both children were within the normal ranges at ages 2 and 3 years.
Conclusion:
Though pregnancy after uterus transplantation is associated with the risk of premature delivery, no abnormalities were observed in the neonatal course and 3-year follow-up results, including the neurodevelopmental status, of two children born prematurely to mothers with a transplanted uterus. This is the first report on neurodevelopmental outcomes in children born after uterus transplantation. More data on children born after this radical procedure of uterine factor infertility treatment are required to support our promising results.
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