Clinical and Imaging Parameters Associated With Impaired Kidney Function in Patients With Acute Decompensated Heart...

Area of Science:

• Cardiology
• Nephrology
• Radiology

Background:

• Acute worsening of cardiac function often leads to kidney dysfunction.
• Patients with acute decompensated heart failure with reduced ejection fraction (HFrEF) are particularly vulnerable.
• Identifying predictors of kidney dysfunction in HFrEF is crucial for timely intervention.

Purpose of the Study:

• To identify clinical and imaging parameters associated with impaired kidney function in patients hospitalized with acute decompensated HFrEF.
• To evaluate the association between perirenal fat thickness and kidney function in this population.

Main Methods:

• Analysis of data from 131 hospitalized patients with acute decompensated HFrEF (left ventricular ejection fraction < 40%).
• Patients categorized by glomerular filtration rate (GFR) at admission: preserved (≥ 60 mL/min/1.73 m²) vs. reduced (< 60 mL/min/1.73 m²).
• Assessment of echocardiographic parameters and perirenal fat thickness via computed tomography.

Main Results:

• 60 patients (46%) had reduced kidney function.
• Increased age, elevated log N-terminal pro b-type natriuretic peptide, and increased perirenal fat thickness were independently associated with reduced kidney function.
• A perirenal fat thickness cutoff of > 12 mm showed 55% sensitivity and 83% specificity for predicting kidney dysfunction.

Conclusions:

• Increased perirenal fat thickness is an independent predictor of impaired kidney function in hospitalized patients with acute decompensated HFrEF.
• Perirenal fat thickness measurement may serve as a valuable imaging biomarker.
• This marker can help identify HFrEF patients at higher risk for developing kidney dysfunction.