Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Drug Excretion: Glomerular Filtration01:02

Renal Drug Excretion: Glomerular Filtration

283
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
283
Renal Clearance01:23

Renal Clearance

1.0K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
1.0K
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

2.8K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
2.8K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

531
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
531

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity and Age Elevate Tissue-Resident Microbiota Akkermansia muciniphila to Induce Oxidative Stress and Promote Breast Cancer Risk.

Cancer research·2026
Same author

BMX-001 acts as a selective chemoradioprotector in rectal cancer.

Redox biochemistry and chemistry·2026
Same author

Serum pro-N-cadherin: a biomarker of cardiac fibrosis and diastolic dysfunction in irradiated non-human primates.

bioRxiv : the preprint server for biology·2026
Same author

Pembrolizumab Plus Quad-Shot Radiotherapy for Recurrent, Unresectable, or Metastatic Head and Neck Cancer: A Nonrandomized Clinical Trial.

JAMA otolaryngology-- head & neck surgery·2026
Same authorSame journal

The Detection of Radiation Effects in the Urine of Rhesus Macaques Using Raman Spectroscopy.

Radiation research·2026
Same author

Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial.

Nutrients·2026

Related Experiment Video

Updated: Jul 12, 2025

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
07:07

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice

Published on: May 10, 2013

43.5K

A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta).

Allison M Tomasino1,2, John D Olson1,2, George W Schaaf1,2

  • 1Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Radiation Research
|October 30, 2023
PubMed
Summary
This summary is machine-generated.

The Schwartz formula accurately estimates glomerular filtration rate (GFR) in rhesus macaques, offering a simpler method for assessing kidney injury after irradiation. This finding aids in the clinical evaluation of renal function in these animals.

More Related Videos

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
06:58

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat

Published on: July 26, 2015

17.4K
Transdermal Measurement of Glomerular Filtration Rate in Mice
07:25

Transdermal Measurement of Glomerular Filtration Rate in Mice

Published on: October 21, 2018

22.0K

Related Experiment Videos

Last Updated: Jul 12, 2025

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
07:07

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice

Published on: May 10, 2013

43.5K
Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
06:58

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat

Published on: July 26, 2015

17.4K
Transdermal Measurement of Glomerular Filtration Rate in Mice
07:25

Transdermal Measurement of Glomerular Filtration Rate in Mice

Published on: October 21, 2018

22.0K

Area of Science:

  • Nephrology
  • Radiology
  • Comparative Medicine

Background:

  • Late effects of irradiation include chronic kidney injury (CKI), impacting morbidity and mortality.
  • Glomerular filtration rate (GFR) is the key indicator of kidney function, but traditional markers may not detect early damage.
  • Current GFR measurement methods are complex and costly, necessitating simpler alternatives.

Purpose of the Study:

  • To evaluate the applicability of the Schwartz formula, commonly used in human pediatrics, for estimating GFR in rhesus macaques.
  • To determine if the Schwartz formula-estimated GFR (eGFR) correlates with iohexol-measured GFR in irradiated and non-irradiated macaques.

Main Methods:

  • Iohexol clearance was measured in 12 rhesus macaques with varying blood urea nitrogen (BUN) levels and 4 controls.
  • GFR was calculated using plasma iohexol concentrations determined by mass spectrometry post-injection.
  • The Schwartz formula was used to calculate eGFR for comparison with iohexol-GFR.

Main Results:

  • A significant positive correlation was observed between iohexol-GFR and Schwartz formula-eGFR.
  • In macaques receiving <6 Gy irradiation, males exhibited higher GFR than females.
  • Macaques with renal irradiation doses >6 Gy showed lower GFR compared to those with <6 Gy doses.

Conclusions:

  • The Schwartz formula provides a rapid, non-invasive, and cost-effective estimation of GFR in rhesus macaques.
  • This method can aid in the clinical assessment of renal function and kidney injury in irradiated macaques.
  • The study validates a simpler approach to GFR estimation in a non-human primate model.