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Updated: Jul 12, 2025

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
ATP-responsive Mn(II)-based T1 contrast agent for MRI
Sellamuthu Anbu1,2, Lawerence Kenning3, Graeme J Stasiuk4
1Departments of Chemistry and Biomedical Sciences, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. bioinorg_anbu@yahoo.com.
Abstract:
A novel diacetylpyridylcarbohydrazide-DAPyCOHz-based manganese(II) chelate with dipicolylamine/zinc(II) (DPA/Zn2+) arms (MnLDPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T1 contrast applications. Compound 2 shows enhanced relaxivity (r1 = 11.52 mM-1 s-1) upon selective ATP binding over other phosphates.
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