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Cognitive dysfunction in pediatric systemic lupus erythematosus: current knowledge and future directions

Ryan Kammeyer1, Ekemini A Ogbu2,3, Jennifer C Cooper4

  • 1Departments of Pediatrics and Neurology, Sections of Child Neurology and Neuroimmunology, University of Colorado School of Medicine, Aurora, CO, USA.

Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence
|October 30, 2023
PubMed

Insights

Cognitive dysfunction in pediatric systemic lupus erythematosus (SLE) is understudied, impacting quality of life. More research is needed on its prevalence, risk factors, and effective management strategies for children with SLE.

Area of Science:

  • Pediatric Neurology
  • Rheumatology
  • Neuroimmunology

Background:

  • Cognitive dysfunction (CD) is a neurologic complication of pediatric systemic lupus erythematosus (SLE).
  • CD in pediatric SLE is poorly understood and understudied.
  • CD can negatively affect long-term socioeconomic status and quality of life.

Purpose of the Study:

  • To review current knowledge on CD in pediatric SLE.
  • To focus on the application of this knowledge to clinical practice.
  • To identify gaps in understanding and suggest future research directions.

Main Methods:

  • Literature review of existing studies on CD in pediatric SLE.
  • Discussion of diagnostic challenges and clinical screening methods.
  • Analysis of potential impacts and interventions for CD.

Main Results:

  • Data on prevalence, risk factors, and optimal management of CD in pediatric SLE are lacking.
  • Current knowledge is insufficient for effective clinical application.
  • Significant gaps exist in understanding the long-term outcomes of CD.

Conclusions:

  • There is a critical need for further research into cognitive dysfunction in pediatric SLE.
  • Improved understanding is essential for developing effective screening, treatment, and management strategies.
  • Addressing CD is crucial for improving the long-term well-being of children with SLE.

Keywords:
Cognitive dysfunctionautoimmune diseasecognitive impairmentneuropsychiatric lupuspediatric systemic lupus erythematosus

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