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Related Experiment Video

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Rapid, Seamless Generation of Recombinant Poxviruses using Host Range and Visual Selection
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Mpox.

Kaileen Jafari1, George A Woodward2

  • 1From the Assistant Professor.

Pediatric Emergency Care
|October 30, 2023
PubMed
Summary

Human mpox (formerly monkeypox) is a rare but emerging zoonotic disease. Pediatric mpox cases are uncommon, but healthcare providers should recognize its features for prompt diagnosis and care.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Pediatrics

Background:

  • Human mpox is a zoonotic viral disease causing smallpox-like illness.
  • First identified in 1970, mpox outbreaks were historically localized to endemic regions.
  • A 2022 global surge led to a Public Health Emergency of International Concern declaration.

Purpose of the Study:

  • To inform pediatric emergency and urgent care providers about mpox in children and adolescents.
  • To highlight the clinical features, treatment, and prophylaxis of mpox in pediatric populations.
  • To raise awareness of mpox as an emerging infectious disease affecting young individuals.

Main Methods:

  • Review of mpox epidemiology and clinical data, focusing on pediatric cases.
  • Analysis of case distribution in nonendemic countries, particularly the US.

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  • Synthesis of information on transmission, clinical presentation, and management strategies.

    • Main Results:

    • Mpox cases in US children and adolescents represented only 0.3% of total cases as of September 2022.
    • Most pediatric infections resulted from direct household contact with an infected individual.
    • The majority of mpox cases globally and in the US occurred in adults, particularly men who have sex with men.

    Conclusions:

    • While uncommon, mpox poses a risk to children and adolescents.
    • Pediatric healthcare providers need to be prepared for potential mpox cases.
    • Awareness of mpox clinical features, treatment, and prophylaxis is crucial for effective pediatric care.