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Deficits of Visual Cortex Function in Acute Acquired Concomitant Esotropia Patients
Yan Hu1,2,3, Shenjiang Wang4, Lianqun Wu1,2,3
1Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China.
Investigative Ophthalmology & Visual Science
|October 30, 2023
Summary
Resting-state fMRI revealed functional deficits in the visual cortex and dorsal pathway in patients with acquired concomitant esotropia (AACE). These findings link AACE to visual processing centers, offering insights for treatment strategies.
Area of Science:
- Neuroscience
- Ophthalmology
- Medical Imaging
Background:
- Acquired concomitant esotropia (AACE) is a complex eye condition.
- Understanding the underlying cortical mechanisms is crucial for effective treatment.
Purpose of the Study:
- To investigate cortical functional deficits in AACE patients using resting-state functional magnetic resonance imaging (rs-fMRI).
Main Methods:
- Collected rs-fMRI data from 25 AACE patients and 25 controls.
- Analyzed amplitudes of low-frequency fluctuation (ALFF) signals using statistical tests.
- Correlated signal changes with clinical features like age of onset and near work.
Main Results:
- AACE patients exhibited decreased ALFF in the middle occipital gyrus bilaterally.
- ALFF in the inferior frontal gyrus correlated with age of onset.
- ALFF in the superior temporal gyrus correlated with near work hours.
- Fusiform gyrus ALFF showed positive correlations with deviation angles.
Conclusions:
- rs-fMRI identified functional deficits in the primary visual cortex and dorsal pathway in AACE.
- Functional changes in the fusiform gyrus were associated with the degree of eye deviation.
- These results highlight the connection between AACE and visual processing centers, informing potential treatments.
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