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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Knowledge-map analysis of bladder cancer immunotherapy.

Zongwei Lv1, Junhui Hou1, Yuan Wang2

  • 1Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Human Vaccines & Immunotherapeutics
|October 30, 2023
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Summary

This bibliometric analysis of bladder cancer immunotherapy reveals key research trends and collaborations. Future directions focus on tumor microenvironment and immune checkpoint inhibitors combined with other therapies.

Keywords:
Bibliometricsbladder cancerdiagnosisimmunotherapyprognosis

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Area of Science:

  • Oncology
  • Immunology
  • Bibliometrics

Background:

  • Bladder cancer (BC) immunotherapy research has rapidly evolved.
  • Understanding global research trends, hotspots, and frontiers is crucial for advancing the field.

Purpose of the Study:

  • To conduct a bibliometric analysis of bladder cancer immunotherapy research from 2000 to 2022.
  • To identify key authors, institutions, countries, journals, and research themes.
  • To explore future research directions in BC immunotherapy.

Main Methods:

  • Bibliometric analysis using VOSviewer software.
  • Analysis of citation, co-authorship, and co-citation data.
  • Categorization of studies into basic research, clinical trials, and prognosis.

Main Results:

  • The United States led in publications and international collaboration.
  • The University of Texas MD Anderson Cancer Center was the most prolific institution.
  • Kamat AM and Lamm DL were highly cited authors, while Chang Yuan and Xu le led collaborative efforts.
  • The Journal of Urology was the most prominent journal.
  • Research themes included basic research, clinical trials, and prognosis.

Conclusions:

  • The USA is a major hub for bladder cancer immunotherapy research.
  • Future research is likely to focus on the tumor microenvironment and immune checkpoint inhibitors (ICIs) in combination therapies.
  • This analysis provides a comprehensive overview of BC immunotherapy research priorities and future directions.