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Telomeres and Telomerase02:41

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
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In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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Related Experiment Video

Updated: Jul 12, 2025

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

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Methods that shaped telomerase research.

Louise Bartle1, Raymund J Wellinger2

  • 1Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Applied Cancer Research Pavilion, 3201 rue Jean-Mignault, Sherbrooke, QC, J1E 4K8, Canada.

Biogerontology
|October 31, 2023
PubMed
Summary
This summary is machine-generated.

Telomerase, an enzyme complex vital for telomere maintenance, has a complex structure and dynamic cellular behavior. Reviewing current and novel methods is timely to understand telomerase ribonucleoprotein (RNP) assembly, function, and disease relevance.

Keywords:
MethodsTelomeraseTelomerase RNATelomere

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Telomere maintenance is crucial for cellular aging and cancer.
  • Telomerase, a ribonucleoprotein (RNP) complex, is central to telomere maintenance.
  • Understanding telomerase's complex structure, function, and cellular dynamics is essential.

Purpose of the Study:

  • To review existing and emerging methodologies for studying telomerase.
  • To highlight how these methods contribute to understanding telomerase RNP biology.
  • To identify key questions addressable by new technologies.

Main Methods:

  • Review of established techniques for telomere length and telomerase activity measurement.
  • Discussion of novel technologies for detailed telomerase RNP analysis.
  • Synthesis of findings from various methodological approaches.

Main Results:

  • Established methods remain critical for fundamental telomere and telomerase assays.
  • Emerging technologies offer unprecedented insights into telomerase RNP structure and function.
  • A comprehensive understanding of telomerase requires integrating data from diverse methodologies.

Conclusions:

  • Methodological advancements are crucial for unraveling telomerase complexity.
  • Future research directions can leverage new techniques to address outstanding questions in telomerase biology.
  • Continued investigation into telomerase mechanisms is vital for understanding human health and disease.