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Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders,

Chongxiang Xue1,2, Keyu Chen1,2, Zezheng Gao1,3

  • 1Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No.5 BeiXianGe Street, Xicheng District, Beijing, 100053, China.

Cell Communication and Signaling : CCS
|October 31, 2023
PubMed

Insights

Diabetic vascular complications (DVCs) stem from endothelial dysfunction caused by hyperglycemia and lipid disorders. Targeting common underlying mechanisms offers new strategies for diabetes mellitus (DM) secondary prevention.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Metabolic Disorders

Background:

  • Diabetic vascular complications (DVCs) are a leading cause of mortality in diabetes mellitus (DM).
  • Endothelial dysfunction is the primary pathogenic event initiating DVCs.
  • Hyperglycemia and dyslipidemia are key metabolic contributors to endothelial dysfunction.

Keywords:
Common mechanismsDiabetes mellitusDiabetic vascular complicationsEndothelial dysfunctionSecondary prevention

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