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Related Experiment Videos

Carcinoma cells may modulate their supporting connective tissue.

S D Vincent, M W Hill

    British Journal of Experimental Pathology
    |October 1, 1986
    PubMed
    Summary

    A poorly-differentiated squamous cell carcinoma line (FS) modified connective tissue, enhancing subsequent normal epidermal growth. This suggests a mechanism for metastasis establishment by carcinoma cells.

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    Medical physics·2017

    Area of Science:

    • Oncology
    • Cell Biology
    • Tissue Engineering

    Background:

    • Squamous cell carcinoma (SCC) is a common skin cancer.
    • Understanding tumor-host interactions is crucial for cancer progression and metastasis.
    • The role of connective tissue modification by tumor cells in supporting normal tissue growth is not well understood.

    Purpose of the Study:

    • To investigate the growth patterns of two chemically-induced murine SCC cell lines.
    • To evaluate the effect of these SCC cell lines on a deep connective tissue graft bed.
    • To determine if tumor cells can alter the graft bed to support normal tissue growth.

    Main Methods:

    • Two chemically-induced murine SCC cell lines (FS: poorly-differentiated, A5: well-differentiated) were used in syngeneic C57Bl/6 mice.
    • Tumorigenicity was assessed by comparing tumor formation with different inocula.
    • A bioassay involving transplantation of epidermal sheets onto pretreated connective tissue graft beds was employed.

    Main Results:

    • The poorly-differentiated FS cell line formed tumors at lower inocula than the well-differentiated A5 cell line.
    • Pretreatment of the connective tissue graft bed with the FS cell line facilitated subsequent growth of normal epidermal sheets.
    • Graft beds treated with the A5 cell line, irradiated tumor cells, or no treatment failed to support normal epidermis growth.

    Conclusions:

    • Carcinoma cell lines can differentially modify the deep connective tissue microenvironment.
    • Poorly-differentiated SCC cells (FS) can alter the connective tissue to support normal epidermal growth.
    • This modification capability may play a role in the establishment of metastatic deposits by carcinoma cells.

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