Related Experiment Video
Updated: Jul 24, 2026

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
Published on: June 25, 2016
Calcium dobesilate-induced hyperpyrexia: A case report
Hui Yang1, Hong-Ling Yuan1, Zhi-Ping Zhang1
1Department of Nephrology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Rationale:
Calcium dobesilate, a vasoprotective and antioxidant agent, is gradually being used for the treatment of chronic kidney disease. Calcium dobesilate-induced hyperpyrexia is a rare clinical event, and few studies have reported it.
Patient Concerns:
The patient took calcium dobesilate, which caused high fever. After stopping calcium dobesilate, his body temperature returned to normal.
Diagnoses:
Based on the medical history, symptoms and signs, the patient was diagnosed with drug fever caused by calcium dobesilate.
Interventions:
Calcium dobesilate was stopped, and supportive treatment was given at the same time.
Outcomes:
The present case was initially misdiagnosed as a fever caused by a bacterial infection, but treatment with the antibiotic moxifloxacin was ineffective. Based on the patient's medical history, laboratory and examination results, body temperature changes, and Naranjo Advanced Drug Response Scale, calcium dobesilate-induced hyperpyrexia was diagnosed. After discontinuation of calcium dobesilate, the patient's body temperature normalized, and no additional episode of fever was observed at follow-up.
Lesson:
Moreover, misdiagnosis and mistreatment of this condition can deteriorate the patient's condition. Herein, we report a case of calcium dobesilate-induced hyperpyrexia that occurred during the treatment of chronic renal insufficiency. Subsequently, a systematic analysis of the patient's diagnosis and treatment was reviewed. If unexplained high fever develops during the use of calcium dobesilate, calcium dobesilate-induced hyperpyrexia should be considered. Accordingly, calcium dobesilate should be discontinued.
Related Concept Videos
Increased Body Temperature
Types of Fever
Here are the different types of fever:
Homeostatic Imbalances in Body Temperature
Hyperthyroidism I: Introduction
Hyperthyroidism II: Pathophysiology
Graves Disease II: Pathophysiology

