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Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model
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Meningitis and sepsis caused by Streptococcus suis in an elderly woman: A CARE-compliant case report

Kuangyi Li1, Shilan Li2, Jiana Hong2

  • 1Department of Emergency Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan City, Guangdong Province, China.

Medicine
|October 31, 2023
PubMed
Abstract

Insights

Streptococcus suis (S suis) infection is rare but serious, causing meningitis and sepsis. Metagenomic sequencing aids rapid diagnosis in patients with neurological symptoms and potential pork exposure.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Neurology

Background:

  • Streptococcus suis (S suis) causes uncommon, life-threatening infections.
  • Clinical presentations range from general symptoms to fatal meningitis.
  • Standard diagnostic methods often lack specificity for timely diagnosis.

Observation:

  • A 70-year-old woman presented with generalized pain, rapidly progressing to fever, intracranial hypertension, and altered consciousness.
  • Blood and cerebrospinal fluid analysis was performed.
  • Metagenomic next-generation sequencing (mNGS) and bacterial cultures were utilized for diagnosis.

Findings:

  • The patient was diagnosed with meningitis and sepsis caused by S suis infection.
  • Prompt anti-infection therapy with meropenem and vancomycin was initiated.
  • The patient recovered fully without residual effects and was discharged.

Implications:

  • S suis infection should be considered in patients with fever, altered consciousness, and intracranial hypertension, particularly with raw pork exposure.
  • Metagenomic next-generation sequencing offers a valuable tool for rapid S suis diagnosis and treatment planning.
  • Public health awareness is crucial for mitigating S suis infection risks.

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