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Fatal invasive pulmonary aspergillosis in non-immunocompromised host: A case report

Wanping Ao¹, Ping Huang¹, Jinjing Wang²

¹Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi city, China.

|October 31, 2023

Abstract

Rationale:

Invasive pulmonary aspergillosis (IPA) is an uncommon but life-threatening disease. The disease often occurs in immunocompromised patients or critically ill patients. Here, we reported that IPA occurred in a non-immunocompromised host.

Patient Concerns:

A 45-year-old man was admitted to the hospital for 1 week due to fever and cough. He was engaged in waste recycling and lived in a dark and humid environment for a long time.

Diagnosis:

Invasive pulmonary aspergillosis.

Interventions:

Next generation sequencing and pathological examination of alveolar lavage fluid indicated aspergillus infection. He received voriconazole infusion after admission. After 5 weeks of antifungal treatment, his condition improved significantly and discharged.

Outcome:

One week after discharge, his condition deteriorated again and returned to the hospital. Unfortunately, he died.

Lesson:

The immunocompetent adults can develop invasive pulmonary aspergillosis if they are exposed to high-risk environments. IPA in non-immunocompromised host should arouse the vigilance of clinicians.

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