Open-source, partially 3D-printed, high-pressure (50-bar) liquid-nitrogen-cooled parahydrogen generator

The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already used in clinical trials, the parahydrogen ($$H$$-based hyperpolarization approaches are less cost-intensive, are scalable, and offer high throughput. However, a $$H$$ generator is necessary. Available commercial $$H$$ generators are relatively expensive (EUR 10 000-150 000). To facilitate the spread of $$H$$-based hyperpolarization studies, here we provide the blueprints and 3D models as open-source for a low-cost (EUR $$) 50-bar liquid-nitrogen-cooled $$H$$ generator.