Related Experiment Video
Updated: Jul 12, 2025
20:36
Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling
Published on: July 4, 2007
8.8K
Predicting functional consequences of recent natural selection in Britain
Lin Poyraz1,2, Laura L Colbran1, Iain Mathieson1
1Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Biorxiv : the Preprint Server for Biology
|October 31, 2023
Summary
Ancient DNA reveals natural selection
Area of Science:
- Human evolutionary genomics
- Population genetics
- Ancient DNA analysis
Background:
- Inferring phenotypic consequences of natural selection from ancient DNA is challenging.
- Non-coding variants likely play a significant role in the phenotypic effects of selection.
- Direct measurement of gene expression in ancient individuals is not possible.
Conclusions:
- Joint-Tissue Imputation (JTI) effectively predicts gene expression changes in ancient populations.
- This approach can identify novel targets of natural selection acting on gene expression.
- Combining genomic selection statistics with JTI models enhances the study of selection using present-day data.
Related Concept Videos
01:38Limits to Natural Selection
31.3K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
31.3K
01:32What is Natural Selection?
115.4K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
115.4K
01:15Natural Selection and Adaptation
217
Natural selection, a fundamental concept in evolutionary biology, is the mechanism by which evolution is driven, favoring organisms that are best adapted to their environments. This process enhances their chances of survival and reproduction. Adaptation, a key outcome of this process, involves genetic modifications that optimize an organism's functionality under specific environmental challenges, such as extreme cold or thinner air at high altitudes.
Beyond physical adaptations,...
Beyond physical adaptations,...
217
01:46Types of Selection
40.5K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
40.5K
02:16Genetics of Speciation
19.3K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
19.3K
01:06Natural Selection and Mating Preferences
107
The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing,...
Females, due to their biological roles in conception, pregnancy, and nursing,...
107