Regulatory Landscape Enrichment Analysis (RLEA) using gaiaAssociation
Eric A Sosa1, Samuel Rosean2, Dónal O'Shea3
1Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
The gaiaAssociation package performs Regulatory Landscape Enrichment Analysis (RLEA) to identify cell types involved in specific phenotypes. This analysis helps understand genomic loci enrichment within cell type-specific regulatory regions.
Area of Science:
- Genomics
- Computational Biology
- Functional Genomics
Background:
- Understanding the regulatory landscape of cell types is crucial for interpreting genomic data.
- Genome-wide association studies (GWAS) identify genetic loci associated with phenotypes but often lack cell type resolution.
Conclusions:
- RLEA, implemented in gaiaAssociation, is a powerful tool for dissecting the cell type-specific regulatory basis of phenotypes.
- The package facilitates the integration of GWAS data with functional genomics data to reveal cell type-specific regulatory mechanisms.
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