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Correlation Between Statin Use and Symptomatic Venous Thromboembolism Incidence in Patients With Ankle Fracture: A
Nour Nassour1, Bardiya Akhbari1, Noopur Ranganathan1
1Foot & Ankle Research and Innovation Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Statin use was associated with a significantly lower incidence of venous thromboembolism (VTE) in patients with ankle fractures. This finding suggests statins may play a protective role against VTE in this patient group.
Area of Science:
- Orthopedic Surgery
- Cardiology
- Vascular Medicine
Background:
- Venous thromboembolism (VTE) is a significant concern in patients with ankle fractures.
- Identifying preventative factors for VTE is crucial for patient management and prophylaxis decisions.
Purpose of the Study:
- To investigate the correlation between statin consumption and the incidence of VTE in patients who sustained an ankle fracture.
Main Methods:
- Retrospective, case-controlled study with a 1:4 ratio of VTE cases to controls.
- Data collected included demographics, hyperlipidemia history, and statin use.
- A random forest classifier model predicted VTE risk based on statin use, BMI, age, and sex.
Main Results:
- Statin users had a significantly lower incidence of VTE (OR = 0.35, P < .001).
- The predictive model achieved an AUROC of 78%, with age and BMI being the strongest predictors besides statins.
Conclusions:
- Statin consumption is significantly associated with a reduced rate of VTE in patients with ankle fractures.
- Statins may offer a protective effect against VTE in this population.
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