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Expression of miRNA-451 and miRNA-885 in Meningiomas
Ozgur Baran1, Adil Can Karaoglu1, Erdogan Kara2
1Department of Neurosurgery, Diyarbakir Gazi Yaşargil Training and Research Hospital, Diyarbakir, Turkey.
Background/Aim:
Meningiomas are one of the most common intracranial tumors, accounting for 30% of the tumors of the central nervous system. MicroRNAs (miRNAs) are noncoding RNAs containing approximately 18-22 nucleotides that regulate gene expression by interfering with transcription or inhibiting translation. Recent studies have reported that miRNAs could provide information about the molecular pathogenesis of several types of tumors. This study aimed to examine the expression levels of miRNA-885 and -451 and to determine their potential roles as biomarkers in meningioma.
Materials And Methods:
In total, 29 patients with meningioma (9 males and 20 females) were included in this study. The expression levels of miRNA were determined using real-time polymerase chain reaction. In addition, receiver operating characteristic curve analysis was used to analyze the predictive potential of miRNAs.
Results:
Our results indicated a significant increase in miRNA-451 expression levels (p=0.003); however, there was no significant change in miRNA-885 expression levels (p=0.139) in patients with meningioma compared with the control group. Moreover, miRNA-885 and miRNA-451 expression levels did not differ significantly based on the histopathological grade of meningioma.
Conclusion:
miRNA-451 may be a novel potential marker for the diagnosis and prognosis, and a target for meningioma treatment.
Insights
MicroRNA-451 expression is significantly increased in meningioma patients, suggesting it may serve as a diagnostic and prognostic biomarker. MicroRNA-885 levels showed no significant change in this study.
Area of Science:
- Neuro-oncology
- Molecular Biology
- Biomarker Discovery
Background:
- Meningiomas represent a significant portion of central nervous system tumors.
- MicroRNAs (miRNAs) are key regulators of gene expression with potential roles in tumorigenesis.
- Investigating specific miRNAs can elucidate tumor pathogenesis and identify biomarkers.
Purpose of the Study:
- To evaluate the expression levels of miRNA-885 and miRNA-451 in meningioma.
- To determine the potential of these miRNAs as diagnostic and prognostic biomarkers for meningioma.
Main Methods:
- Real-time polymerase chain reaction (PCR) was used to quantify miRNA expression in 29 meningioma patients.
- Receiver operating characteristic (ROC) curve analysis assessed the predictive value of the miRNAs.
- Expression levels were correlated with histopathological grade.
Main Results:
- A significant upregulation of miRNA-451 was observed in meningioma patients compared to controls (p=0.003).
- No significant difference in miRNA-885 expression was found between patients and controls (p=0.139).
- Neither miRNA-885 nor miRNA-451 expression levels varied significantly with meningioma histopathological grade.
Conclusions:
- miRNA-451 shows promise as a novel biomarker for meningioma diagnosis and prognosis.
- miRNA-451 may also represent a potential therapeutic target for meningioma treatment.
