Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Skin and Tumor Dual-Permeable Tumoricidal Gel for cGAS-STING Activation-Enhanced Chemoimmunotherapy.

ACS nano·2026

Same author

Carbon Nanostructure-Initiator Mass Spectrometry for Metabolic Biomarker Detection of Prediabetes.

Analytical chemistry·2026

Same author

Targeting the mevalonate pathway with statins overcomes acquired resistance to KRAS<sup>G12C</sup> inhibitors in non-small cell lung cancer.

Experimental hematology & oncology·2026

Same author

Therapeutic applications and prospects of inhalable mesoporous silica nanoparticles in pulmonary diseases.

Nanoscale·2026

Same author

Corynoline and Extracellular Vesicles Co-Loaded Scaffold Accelerates Vascularized Bone Regeneration with Photothermal Stimulation.

ACS biomaterials science & engineering·2026

Same author

Tackling the Orexin Conundrum: An Optimized LC-MS/MS Method Demonstrates Accurate CSF Quantification and Absence in Peripheral Blood.

Analytical chemistry·2026

Search research articles

Related Experiment Video

Updated: Jul 12, 2025

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Published on: April 16, 2019

Engineered Silica Nanoparticles for Nucleic Acid Delivery.

Yue Zhang¹, Yingjie Yu¹, Yannan Yang^1,2

¹Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, 4072, Australia.

|October 31, 2023

Summary

This summary is machine-generated.

Silica nanoparticles (SiNPs) offer a promising solution for delivering nucleic acid therapeutics, overcoming challenges like poor cell entry and instability. This review details SiNP designs for enhanced gene delivery and biomedical applications.

Keywords:

drug delivery nucleic acid silica nanoparticles

More Related Videos

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

Related Experiment Videos

Last Updated: Jul 12, 2025

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Published on: April 16, 2019

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

Area of Science:

Biomedical Engineering
Nanotechnology
Molecular Biology

Background:

Nucleic acid-based drugs show therapeutic potential but face delivery barriers.
Poor cellular membrane permeability and instability hinder effective nucleic acid drug delivery.
Specialized delivery vehicles are essential for protecting and transporting nucleic acids.

Purpose of the Study:

To review recent advancements in silica nanoparticle (SiNP) design for nucleic acid delivery.
To summarize SiNP applications in enhancing the delivery of various nucleic acid types.
To highlight tailored SiNP designs based on nucleic acid characteristics and discuss future research directions.

Main Methods:

Literature review focusing on SiNPs for nucleic acid delivery.
Classification of nucleic acids by function and introduction of their mechanisms.
Summarization of SiNP-enhanced delivery performance and biomedical applications for each nucleic acid type.

Main Results:

SiNPs are effective nanovectors and bioregulators for gene delivery.
Tailored SiNP designs improve delivery efficiency for specific nucleic acids.
SiNPs demonstrate diverse biomedical applications in nucleic acid therapy.

Conclusions:

SiNPs present a viable strategy to overcome nucleic acid delivery challenges.
Further research into tailored SiNP designs will advance next-generation nucleic acid delivery systems.
This review provides insights into the burgeoning field of SiNP-based nucleic acid therapeutics.