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Updated: Jul 12, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

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A novel U-shaped relationship between serum klotho and abdominal aortic calcification in the general population

Na Wei1, Zuolei Shi2, Yan Gong3

  • 1Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, Shandong, China.

Cardiovascular Journal of Africa
|October 31, 2023
PubMed

Insights

Serum soluble α-klotho (SSKL) is inversely associated with abdominal aortic calcification (AAC) in the general population. This U-shaped relationship is influenced by age and smoking status, suggesting klotho’s protective role against cardiovascular disease.

Area of Science:

  • Cardiology
  • Gerontology
  • Biochemistry

Background:

  • Abdominal aortic calcification (AAC) is a significant predictor of cardiovascular events.
  • Klotho, an anti-aging protein, exhibits cardioprotective properties.
  • The link between klotho and AAC in the general population remains unclear.

Purpose of the Study:

  • To investigate the association between serum soluble α-klotho (SSKL) and AAC.
  • To explore potential modifiers of this relationship, including age and smoking habits.

Main Methods:

  • Analysis of 2,327 participants from the National Health and Nutrition Examination Survey.
  • Multivariate logistic regression and generalized additive models were used.
  • Stratified analyses examined subgroups based on age and smoking status.

Main Results:

  • A negative correlation was observed between lnSSKL and AAC after adjusting for confounders.
  • The relationship exhibited a U-shaped curve with an inflection point at 7.01 pg/ml.
  • The inverse association persisted in men and smokers.

Conclusions:

  • Serum soluble α-klotho (SSKL) is negatively associated with abdominal aortic calcification (AAC) in the general population.
  • The relationship is U-shaped and modulated by age and smoking.
  • These findings highlight klotho's potential role in cardiovascular health.
Abstract

Keywords:
NHANESU‐shaped relationshipabdominal aortic calcificationcross‐sectional studyklotho

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