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Relationship between adiponectin and copeptin levels with long-term cardiovascular mortality in ST-segment elevation

Ayça Türer Cabbar1, Ersin Yıldırım2, Özge Güzelburç Çalbayram3

  • 1Department of Cardiology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.

Cardiovascular Journal of Africa
|October 31, 2023
PubMed

Insights

Adiponectin and copeptin levels can predict cardiovascular mortality risk in ST-segment elevation myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). Higher levels indicate a greater risk of death from cardiovascular causes.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Research

Background:

  • Cardiovascular mortality remains a significant concern in ST-segment elevation myocardial infarction (STEMI) patients.
  • Identifying reliable prognostic markers is crucial for risk stratification and management.
  • Adiponectin and copeptin are potential biomarkers implicated in cardiovascular disease.

Purpose of the Study:

  • To investigate the prognostic value of adiponectin and copeptin levels for cardiovascular mortality (CvsM) in STEMI patients.
  • To determine if these biomarkers can predict long-term CvsM after percutaneous coronary intervention (PCI).

Main Methods:

  • A cohort of STEMI patients undergoing PCI between November 2010 and April 2011 was followed for over eight years.
  • Baseline demographic, angiographic, echocardiographic, and laboratory data, including adiponectin and copeptin levels, were analyzed.
  • Statistical analysis was performed to identify predictors of CvsM.

Main Results:

  • The study included 98 patients (78 males, 20 females).
  • The CvsM rate was 26.66% at 112 months follow-up.
  • Adiponectin was an independent predictor of mortality. Cut-off values of ≥ 8950 ng/ml for adiponectin and ≥ 7.41 ng/ml for copeptin were associated with 3.01- and 2.83-times higher CvsM risk, respectively.

Conclusions:

  • Adiponectin levels serve as a significant predictor of CvsM in STEMI patients post-PCI.
  • Elevated levels of both adiponectin and copeptin are associated with an increased risk of cardiovascular mortality.
Abstract

Keywords:
ST‐segment elevation myocardial infarctionadiponectincopeptinmortality

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