Biosensors for natriuretic peptides in cardiovascular diseases. A review

Area of Science:

• Biomedical Engineering
• Cardiology
• Clinical Diagnostics

Background:

• Heart failure (HF) is a significant clinical syndrome with high morbidity and mortality.
• Accurate biomarkers are crucial for early diagnosis and precise monitoring of HF.
• Natriuretic peptides have demonstrated significant potential as biomarkers in HF assessment.

Purpose of the Study:

• To provide a comprehensive overview of heart failure, including its pathogenesis and diagnostic features.
• To elucidate the role of natriuretic peptides in HF, detailing their characteristics and biomarker potential.
• To review the advancements in biosensor technology and existing natriuretic peptide biosensors for HF monitoring.

Main Methods:

• Literature review focusing on heart failure, natriuretic peptides, and biosensor technology.
• Analysis of the pathophysiological roles and diagnostic utility of natriuretic peptides.
• Examination of the technological evolution and application of biosensors for natriuretic peptide detection.

Main Results:

• Natriuretic peptides are established indicators in HF assessment.
• Biosensors offer promising new avenues for medical diagnostics and disease monitoring.
• Advancements in biosensor technology are enabling more sensitive and specific detection of natriuretic peptides.

Conclusions:

• Natriuretic peptides are vital biomarkers for heart failure management.
• Biosensors represent a rapidly evolving field with significant potential for improving HF diagnosis and monitoring.
• The integration of natriuretic peptide detection via biosensors can enhance patient outcomes through early intervention.