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Related Experiment Video

Updated: Jul 12, 2025

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Neonatal varicella.

Katherine Longbottom¹, Hermione Lyall²

¹Paediatric Infectious Diseases, NHS Greater Glasgow and Clyde, Royal Hospital for Children, Glasgow, UK katherine.longbottom@ggc.scot.nhs.uk.

Archives of Disease in Childhood

|October 31, 2023

Summary

This summary is machine-generated.

Primary varicella zoster virus (VZV) infection during late pregnancy can lead to neonatal varicella. Prompt VZV immunoglobulin and aciclovir treatment, alongside universal vaccination, are key to preventing severe outcomes in newborns.

Keywords:

Communicable Diseases Infectious Disease Medicine Neonatology Paediatrics Virology

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Published on: September 15, 2014

Area of Science:

Obstetrics and Gynecology
Infectious Diseases
Pediatrics

Background:

Primary varicella zoster virus (VZV) infection in late pregnancy poses a risk of transplacental transmission.
Neonatal varicella can lead to severe disease, particularly in infants born shortly before or after maternal rash onset.

Purpose of the Study:

To outline the risks associated with primary VZV infection during pregnancy.
To recommend management strategies for preventing and treating neonatal varicella.

Main Methods:

Review of current literature on VZV transmission during pregnancy.
Analysis of risk factors for severe neonatal varicella.
Evaluation of prophylactic and therapeutic interventions.

Main Results:

Infants born 5 days before to 2 days after maternal rash onset face the highest risk of severe neonatal varicella.
Post-exposure prophylaxis with VZV immunoglobulin and aciclovir treatment are recommended for high-risk infants.
Universal VZV vaccination is effective in reducing the incidence of neonatal varicella.

Conclusions:

Maternal VZV infection in late pregnancy requires careful management to prevent neonatal complications.
Timely intervention with immunoglobulin and antiviral therapy, coupled with vaccination, is crucial for infant protection.