Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Benzene hematotoxicity and leukemogenesis.

E P Cronkite

    Blood Cells
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Benzene exposure causes leukemia in mice, even at lower concentrations. This study questions the "one hit" hypothesis, suggesting further research is needed on dose-response relationships for benzene carcinogenicity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dynamics of hemopoietic proliferation in man and mice studied by H3-thymidine incorporation into DNA.

    Progress in nuclear energy. Series 6 Biological sciences·2014
    Same author

    Injuries produced by the atomic bomb; observations on animals exposed at Bikini.

    The American journal of pathology·2010
    Same author

    The hematology of the Bikini animals.

    The American journal of pathology·2010
    Same author

    Telomerase activity in mouse myeloid leukemic cells and in cells from normal hematopoietic systems.

    Blood cells, molecules & diseases·2001
    Same author

    Characterization of genetic instability in radiation- and benzene-induced murine acute leukemia.

    Mutation research·1999
    Same author

    Advantages of the CBA mouse in leukemogenesis research.

    Blood cells, molecules & diseases·1999
    Same journal

    In vitro and in vivo studies of stromal niches.

    Blood cells·1994
    Same journal

    Differential manipulation of normal and chronic myeloid leukemia stem cell proliferation in vitro.

    Blood cells·1994
    Same journal

    Enrichment for primitive hemopoietic progenitors of marrow cells from 5-fluorouracil-treated mice and normal mice.

    Blood cells·1994
    Same journal

    Protein tyrosine phosphorylation in the regulation of hematopoiesis by receptors of the cytokine-receptor superfamily.

    Blood cells·1994
    Same journal

    Lysis of blood platelets by human osteosarcoma cells in vitro.

    Blood cells·1994
    Same journal

    Development of hemopoietic bone marrow within the ectopic bone induced by bone morphogenetic protein.

    Blood cells·1994
    See all related articles

    Area of Science:

    • Toxicology
    • Carcinogenesis
    • Hematology

    Background:

    • Benzene is a known human carcinogen.
    • Regulatory agencies propose a
    • one hit
    • linear no-threshold model for benzene's carcinogenic effects.
    • Experimental proof for this model is lacking.

    Purpose of the Study:

    • To investigate the leukemogenic and other biological effects of benzene exposure in mice.
    • To evaluate dose-response relationships for benzene exposure.
    • To test the
    • one hit hypothesis
    • for benzene carcinogenicity.

    Main Methods:

    • CBA/Ca male mice were exposed to varying concentrations of benzene vapor.

    Related Experiment Videos

  • Exposure durations and frequencies were standardized (e.g., 6 hrs/day, 5 days/week).
  • Hematological parameters and bone marrow cellularity were assessed.

    • Main Results:

    • High concentrations (300 ppm) were highly leukemogenic.
    • Lower concentrations (100 ppm) also induced leukemia.
    • Exposure to 25-400 ppm caused increasing lymphopenia.
    • 100 ppm exposure led to anemia, decreased marrow stem cells, and reduced marrow cellularity.

    Conclusions:

    • Benzene exposure demonstrates leukemogenic and other adverse hematological effects in mice.
    • Observed effects at 25 ppm, near permissible exposure limits, raise concerns.
    • Further dose-effect studies are crucial to validate the
    • one hit hypothesis
    • and understand benzene's complex dose-response.