Related Experiment Video

Updated: Jul 12, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

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A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling.

Jesús Giraldo1, Jesper J Madsen2, Xudong Wang2

  • 1Laboratory of Molecular Neuropharmacology and Bioinformatics, Unitat de Bioestadística and Institut de Neurociències, Universitat Autònoma de Barcelona (J.G.), Bellaterra, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (J.G.), CIBERSAM, Spain; Unitat de Neurociència Traslacional, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT), Institut de Neurociències, Universitat Autònoma de Barcelona (J.G.), Spain; Global and Planetary Health, College of Public Health (J.J.M.), Center for Global Health and Infectious Diseases Research, College of Public Health (J.J.M.), Department of Molecular Medicine, Morsani College of Medicine (J.J.M.), Department of Molecular Biosciences (X.W., L.Y.), University of South Florida, Tampa, Florida; Department of Pharmacology and Chemical Biology, University of PittsburghSchool of Medicine (L.W., C.Z.), University of Pittsburgh, Pittsburgh, Pennsylvania; and Lee Moffitt Cancer Center & Research Institute, Tampa, Florida (L.Y.) Jesus.Giraldo@uab.es libinye@usf.edu.

Molecular Pharmacology
|October 31, 2023
PubMed
Summary

This study introduces a new mathematical model for G protein-coupled receptor (GPCR) signaling efficacy, moving beyond the simple ON/OFF switch. It quantifies multiple receptor states to better understand ligand responses and develop more accurate signaling models.

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