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Related Experiment Video

Updated: Jul 12, 2025

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
05:52

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

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Intelligent Vascularized 3D/4D/5D/6D-Printed Tissue Scaffolds.

Xiaoyu Han1,2, Qimanguli Saiding1, Xiaolu Cai3

  • 1Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, People's Republic of China.

Nano-Micro Letters
|November 1, 2023
PubMed
Summary

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Vascularization is crucial for bone tissue engineering. This study reviews advanced additive manufacturing techniques, like 3D printing, for creating smart vascular scaffolds to improve tissue regeneration.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Blood vessels are vital for delivering nutrients and removing waste, making vascularization essential for tissue engineering.
  • Scaffold-based tissue repair, particularly for bone, relies on functional vascular networks.
  • Additive manufacturing (AM), including 3D printing, offers precise control over scaffold properties for vascularized tissue engineering.

Purpose of the Study:

  • To systematically review the importance of vascularization in tissue engineering.
  • To highlight research progress and future prospects of vascularized 3D printed scaffolds.
  • To discuss advancements in intelligent vascularized tissue regeneration.

Main Methods:

  • Systematic review of neovascularization and vascularization in bone tissue engineering.
Keywords:
Additive manufacturingIntelligentOsteogenesisTissue engineeringVascularization

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Last Updated: Jul 12, 2025

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  • Categorization of vascularized 3D printed scaffold materials (functional, cell-based, carrier-loaded, bionic).
  • Review of vascularized AM applications in various tissue types (vascular, cardiovascular, muscle, soft tissue).

    • Main Results:

    • Vascularization is critical for the success of tissue-engineered constructs.
    • Four main categories of vascularized 3D printed scaffolds have emerged.
    • AM enables precise tuning of mechanical and biological properties for smart vascular scaffolds.

    Conclusions:

    • Additive manufacturing holds significant promise for creating advanced vascularized tissue scaffolds.
    • Intelligent vascularized tissue regeneration requires addressing current challenges and fostering further development.
    • The integration of vascularization strategies with AM techniques is key to future regenerative medicine breakthroughs.