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Hypothyroidism After Use of Immune Checkpoint Inhibitor Therapy in Patient With Graves' Disease: Cure?

Rajeev Sharma1

  • 1Division of Endocrinology, Roswell Park Comprehensive Cancer Center & Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, New York, NY 14203, USA.

JCEM Case Reports
|November 1, 2023
PubMed

Immune checkpoint inhibitors (ICIs) are frequently used as treatment for many malignancies. Immune-related adverse events (irAEs) due to use of ICIs are common. Thyroid involvement is the most common endocrine irAE. Here, we present an unusual case of Graves' disease potentially cured due to destructive thyroiditis caused by inflammation due to ICIs. Thyroid irAEs are more common with programmed cell death protein-1 (PD-1) inhibitor or programmed cell death-ligand 1 (PD-L1) inhibitors than cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitors. Baseline and serial monitoring of thyroid function tests is recommended.

Keywords:
Graves' diseaseantithyroid drug (ATD)hypothyroidismimmune checkpoint inhibitorsprogrammed cell death protein-1 (PD-1) inhibitorthyroid-stimulating hormonethyroiditis

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