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Updated: Jul 12, 2025
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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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Late-Onset Isolated Growth Hormone Deficiency
Julie G Samuels1, Sri Nikhita Chimatapu2, Martin O Savage3
1Division of Pediatric Endocrinology and Diabetes, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
JCEM Case Reports
|November 1, 2023
Summary
Growth hormone deficiency (GHD) can develop over time in children with short stature. Longitudinal monitoring during puberty is crucial for accurate diagnosis and timely growth hormone treatment.
Area of Science:
- Pediatrics
- Endocrinology
- Growth Disorders
Background:
- Isolated growth hormone deficiency (GHD) is a condition affecting childhood growth.
- Diagnosis typically involves growth hormone stimulation tests (GHST).
Observation:
- Two male patients presented with growth failure and short stature during adolescence.
- Initial GHST results were borderline or normal, but height declined further with puberty.
- Repeat GHST during puberty, with low testosterone levels, confirmed GHD in both patients.
Findings:
- Patient 1 showed a decrease in peak GH from 16.9 ng/mL to 5.4 ng/mL.
- Patient 2 showed a decrease in peak GH from 19 ng/mL to 9.2 ng/mL.
- GH treatment significantly improved height velocity in both patients.
Implications:
- GHD diagnosis requires longitudinal assessment, not solely relying on a single GHST.
- Monitoring growth and hormone levels throughout puberty is essential for identifying GHD.
- Timely intervention with growth hormone therapy can improve adult height outcomes.
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