Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma fibronectin.

T M Saba

    British Journal of Hospital Medicine
    |November 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Critically ill patients with multiple organ failure often show plasma fibronectin deficiency and impaired phagocytic function. These factors may contribute to the development of organ failure in septic injury.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Transglutaminase-mediated fibronectin multimerization in lung endothelial matrix in response to TNF-alpha.

    American journal of physiology. Lung cellular and molecular physiology·2000
    Same author

    Increased recycling of (alpha)5(beta)1 integrins by lung endothelial cells in response to tumor necrosis factor.

    Journal of cell science·2000
    Same author

    Hepatic fibronectin matrix turnover in rats: involvement of the asialoglycoprotein receptor.

    The American journal of physiology·1999
    Same author

    Lung matrix incorporation of plasma fibronectin reduces vascular permeability in postsurgical bacteremia.

    The American journal of physiology·1999
    Same author

    Circulating cellular fibronectin may be a natural ligand for the hepatic asialoglycoprotein receptor: possible pathway for fibronectin deposition and turnover in the rat liver.

    Hepatology (Baltimore, Md.)·1998
    Same author

    TNF-alpha-induced matrix Fn disruption and decreased endothelial integrity are independent of Fn proteolysis.

    The American journal of physiology·1998
    Same journal

    The autopsy in the 1990s.

    British journal of hospital medicine·1999
    Same journal

    Screening for breast cancer.

    British journal of hospital medicine·1999
    Same journal

    Cost-effective monotherapy of concomitant benign prostatic hyperplasia and hypertension.

    British journal of hospital medicine·1999
    Same journal

    Liposarcoma: a review of current diagnosis and management.

    British journal of hospital medicine·1999
    Same journal

    How to do it in surgery: laparoscopic rectopexy.

    British journal of hospital medicine·1999
    Same journal

    The management of ovarian cancer.

    British journal of hospital medicine·1999
    See all related articles

    Area of Science:

    • Biomedical science
    • Sepsis research
    • Trauma and burn patient care

    Background:

    • Critically ill patients, including those with sepsis, trauma, or burns, frequently develop multiple organ failure.
    • Plasma fibronectin deficiency and impaired reticuloendothelial system phagocytic function are common in these patients.
    • These conditions are associated with increased lung vascular permeability during sepsis and intravascular coagulation.

    Purpose of the Study:

    • To explore the role of plasma fibronectin in the development of multiple organ failure.
    • To highlight the significance of fibronectin in septic injury.

    Main Methods:

    • Review of existing literature on plasma fibronectin.
    • Analysis of clinical observations in critically ill patients.

    Related Experiment Videos

  • Correlation of fibronectin levels with organ failure and sepsis markers.

    • Main Results:

    • Plasma fibronectin deficiency is a consistent finding in multiple organ failure.
    • Reticuloendothelial phagocytic dysfunction is linked to fibronectin deficiency.
    • Altered lung vascular permeability is exacerbated by these factors in sepsis.

    Conclusions:

    • Plasma fibronectin plays a crucial role in maintaining vascular integrity and immune function.
    • Fibronectin deficiency may be a key factor in the pathophysiology of multiple organ failure in septic patients.
    • Further research into fibronectin replacement or augmentation could offer therapeutic strategies.