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Transdermal Measurement of Glomerular Filtration Rate in Mice

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Published on: October 21, 2018

Rifampin-Associated Renal Failure.

Kathleen Miller¹, Helmut Rennke², Eugene Richardson³

¹Department of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts.

Annals of Internal Medicine. Clinical Cases

|November 1, 2023

Summary

This summary is machine-generated.

Rifampin, used for tuberculosis, can rarely cause acute renal failure. This case highlights heme pigment injury as a potential cause of kidney damage in patients treated with rifampin.

Keywords:

Acute renal failure Bilirubin Case series Hemoglobin Hemolytic anemia Hospital medicine Medical dialysis Nephritis Pigment associated nephropathy Platelets Renal failure Rifampin Tuberculosis

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Area of Science:

Nephrology
Infectious Diseases
Pharmacology

Background:

Rifampin is a cornerstone treatment for tuberculosis (TB).
Severe adverse events from rifampin are uncommon, but acute renal failure has been documented, often linked to acute interstitial nephritis.
Heme pigment-related kidney injury is a recognized, though less common, cause of acute kidney injury.

Purpose of the Study:

To report a case of acute renal failure secondary to heme pigment-induced nephropathy in a patient treated with rifampin for latent tuberculosis.
To emphasize the importance of considering rifampin as a potential etiology for acute kidney injury when other causes are not apparent.

Main Methods:

Case report detailing a patient's clinical presentation, treatment, and diagnostic workup.
Review of literature regarding rifampin-induced nephrotoxicity and heme pigment nephropathy.

Main Results:

A patient developed acute renal failure while on daily rifampin therapy for latent tuberculosis.
Renal biopsy and clinical findings were consistent with heme pigment-induced acute tubular injury.
No other identifiable cause for the acute renal failure was found.

Conclusions:

Rifampin can cause acute renal failure through mechanisms beyond acute interstitial nephritis, including heme pigment nephropathy.
Clinicians should consider rifampin as a potential cause of acute kidney injury, even in the context of latent tuberculosis treatment.
Prompt recognition and management are crucial for favorable outcomes in drug-induced kidney injury.