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Related Experiment Videos

Trazodone-induced mania.

H Y Knobler, S Itzchaky, D Emanuel

    The British Journal of Psychiatry : the Journal of Mental Science
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    Trazodone can induce manic symptoms in patients with bipolar depression. These symptoms subsided after discontinuing or reducing trazodone treatment, with two bipolar cases being the first reported instances.

    Area of Science:

    • Psychiatry
    • Pharmacology
    • Neuroscience

    Background:

    • Trazodone is an antidepressant medication commonly prescribed for major depressive disorder.
    • Antidepressant-induced mania is a recognized phenomenon, particularly in individuals with underlying bipolar disorder.

    Observation:

    • Three patients diagnosed with depression (two bipolar, one unipolar) exhibited manic symptoms after initiating trazodone therapy.
    • The emergence of manic symptoms was directly linked to trazodone administration.

    Findings:

    • Manic symptoms in these patients resolved upon dose reduction or discontinuation of trazodone.
    • This study reports the first two cases of trazodone-induced mania in bipolar depressed patients.

    Implications:

    Related Experiment Videos

    • Clinicians should exercise caution when prescribing trazodone to patients with bipolar depression.
    • This highlights the importance of monitoring for manic switch in patients treated with trazodone, especially those with bipolar disorder.