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Related Concept Videos

Protein Families02:47

Protein Families

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
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MFPPDB: a comprehensive multi-functional plant peptide database.

Yaozu Yang1,2,3, Hongwei Wu1, Yu Gao1

  • 1School of Information and Computer, Anhui Agricultural University, Hefei, China.

Frontiers in Plant Science
|November 1, 2023
PubMed
Summary
This summary is machine-generated.

A new database, MFPPDB, catalogs over 1.4 million plant-derived peptides with therapeutic functions. This resource accelerates research by providing efficient access to multi-functional plant peptides for drug discovery.

Keywords:
databasemulti-functionalpeptidomesplanttherapeutic peptide

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Area of Science:

  • Biochemistry and Molecular Biology
  • Pharmacology and Drug Discovery
  • Bioinformatics and Computational Biology

Background:

  • Plants naturally produce bioactive peptides for defense.
  • Experimental verification of plant-derived peptide functions is resource-intensive and time-consuming.
  • There is a need for efficient and accurate methods to predict therapeutic functions of plant peptides.

Purpose of the Study:

  • To develop a comprehensive repository for plant peptides with predicted therapeutic functions.
  • To facilitate the prediction and development of plant-derived peptides for therapeutic applications.
  • To expedite research in plant peptidomics by providing a searchable database.

Main Methods:

  • Development of the Multi-Functional Plant Peptide Database (MFPPDB).
  • Inclusion of 1,482,409 plant peptides from 121 plant species with single or multiple predicted functions.
  • Categorization of peptides into 41 functional types (e.g., anti-bacterial, anti-cancer).
  • Integration of physicochemical properties and search functionalities (by species, ID, function, isoelectric point, molecular weight).
  • Cross-referencing predicted peptides with nine existing curated databases to identify functional potentials.

Main Results:

  • MFPPDB contains 1,482,409 plant-origin therapeutic peptides.
  • Peptides cover 41 functional categories, including antimicrobial, antiviral, and anticancer activities.
  • At least 293,408 peptides were identified with functional potentials through database matching.
  • A user-friendly web interface allows access to detailed peptide information.

Conclusions:

  • MFPPDB serves as a valuable integrated resource for plant peptides with diverse therapeutic functions.
  • The database significantly aids comprehensive research in plant peptidomics and accelerates drug discovery.
  • MFPPDB is freely accessible, promoting wider scientific exploration and application of plant-derived peptides.