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Updated: Jul 12, 2025
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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When to discontinue renal replacement therapy. what do we know?
Naomi Boyer1, F Perschinka2, Michael Joannidis2
1Department of Critical Care and Surrey Peri-Operative, Anaesthesia and Critical Care Collaborative Research Group, Royal Surrey Hospital, Guildford, Surrey, UK.
Current Opinion in Critical Care
|November 1, 2023
Summary
Discontinuing renal replacement therapy in intensive care patients requires more research. Current observational studies show promise with urine output and novel biomarkers, but no definitive criteria exist for successful weaning.
Area of Science:
- Nephrology
- Intensive Care Medicine
- Critical Care
Background:
- Acute kidney injury is a frequent complication in intensive care units.
- Renal replacement therapy (RRT) is a critical supportive measure for these patients.
- While RRT initiation has been extensively studied, evidence on its cessation is limited.
Conclusions:
- Determining successful weaning from RRT is challenging due to sparse evidence.
- Urine output is commonly considered, but its predictive value needs further validation.
- Novel biomarkers require robust study designs to assess their utility.
- Further research, particularly using multivariate models, is essential to improve prediction and success rates for RRT cessation.
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