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Exploring TBL1XR1 and NCOR1 Expression in B-cell Lymphoma Subtypes: Interaction With DNA Damage Repair Genes
Adnan Mansoor1, Ariz Akhter2, Mahboobsadat Hamidi2
1Department of Pathology & Laboratory Medicine, University of Calgary and Alberta Precision Laboratories (APL), Calgary, Alberta, Canada; adnan.mansoor@albertaprecisionlabs.ca.
Anticancer Research
|November 1, 2023
Summary
Transducin β-like 1 X-linked receptor 1 (TBL1XR1) and nuclear receptor corepressor 1 (NCOR1) show varied expression in B-cell lymphomas. TBL1XR1
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- B-cell lymphomas exhibit diverse genetic anomalies impacting B-cell differentiation.
- Understanding germinal center (GC) molecular dynamics is crucial for targeted therapies.
- Transducin β-like 1 X-linked receptor 1 (TBL1XR1) and nuclear receptor corepressor 1 (NCOR1) are key GC modulators with established roles in various cancers.
Purpose of the Study:
- To investigate the prognostic roles and expression patterns of TBL1XR1 and NCOR1 in B-cell lymphomas.
- To explore the relationship between TBL1XR1/NCOR1 expression and B-cell lymphoma subtypes.
- To identify potential molecular mechanisms, such as DNA repair, influenced by TBL1XR1.
Main Methods:
- Digital RNA quantification (Nanostring) was used to analyze TBL1XR1 and NCOR1 expression in 188 B-cell lymphoma specimens.
- Four subtypes were analyzed: follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL-NOS), primary testicular lymphoma (PTL), and plasmablastic lymphoma (PBL).
- Expression levels were compared and correlated with 730 ontogenically linked genes, including DNA Damage repair (DDR) genes.
Main Results:
- TBL1XR1 expression was significantly higher in PTL-ABC vs. DLBCL-NOS-ABC subtypes.
- TBL1XR1 expression was diminished in FL but elevated in DLBCL-NOS GCB-subtypes compared to FL.
- A strong inverse correlation between TBL1XR1 and NCOR1 was found in PBL, and TBL1XR1 showed association with DDR genes.
Conclusions:
- TBL1XR1 and NCOR1 exhibit distinct expression patterns across B-cell lymphoma subtypes.
- The association of TBL1XR1 with DDR genes suggests a role in DNA repair mechanisms.
- These findings offer insights into potential novel therapeutic strategies for B-cell lymphomas.
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