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Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: Jul 12, 2025

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

Monochorionic Twins: TTTS, TAPS, and Selective Fetal Growth Restriction.

Matthew A Shanahan^1,2, Michael W Bebbington³

¹Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine.

Clinical Obstetrics and Gynecology

|November 1, 2023

Summary

Monochorionic twin pregnancies present unique risks due to placental differences. Understanding these complications, like twin-to-twin transfusion syndrome, enables effective fetal therapies.

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Last Updated: Jul 12, 2025

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Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

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Published on: September 5, 2011

Area of Science:

Obstetrics and Gynecology
Perinatology
Maternal-Fetal Medicine

Background:

Twin gestations are increasing, necessitating a deeper understanding of associated risks.
Monochorionic twins share a placenta, leading to specific complications.
Key complications include twin-to-twin transfusion syndrome, twin anemia-polycythemia sequence, and selective fetal growth restriction.

Purpose of the Study:

To elucidate the risks inherent in monochorionic twin pregnancies.
To connect placental differences to specific pregnancy complications.
To highlight advancements in fetal therapy for these conditions.

Main Methods:

Review of obstetric literature focusing on twin gestations.
Analysis of placentation in monochorionic twins.
Examination of the pathophysiology of twin pregnancy complications.

Main Results:

Monochorionic placentation is linked to specific adverse outcomes.
Understanding pathophysiology aids in identifying at-risk pregnancies.
Fetoscopic laser coagulation is an effective therapy for twin-to-twin transfusion syndrome.

Conclusions:

Knowledge of monochorionic placentation is crucial for managing twin pregnancies.
Directed fetal therapy has significantly improved outcomes for certain twin complications.
Continued research is vital for optimizing care in high-risk twin gestations.