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Updated: Jul 12, 2025
Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
Published on: August 7, 2018
Targeting necroptosis in fibrosis
Emad H M Hassanein1, Islam M Ibrahim2, Mostafa S Abd El-Maksoud2
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt. emadhassanien@azhar.edu.eg.
Abstract:
Necroptosis, a type of programmed cell death that resembles necrosis, is now known to depend on a different molecular mechanism from apoptosis, according to several recent studies. Many efforts have reported the possible influence of necroptosis in human disorders and concluded the crucial role in the pathophysiology of various diseases, including liver diseases, renal injuries, cancers, and others. Fibrosis is the most common end-stage pathological cascade of several chronic inflammatory disorders. In this review, we explain the impact of necroptosis and fibrosis, for which necroptosis has been demonstrated to be a contributing factor. We also go over the inhibitors of necroptosis and how they have been applied to fibrosis models. This review helps to clarify the role of necroptosis in fibrosis and will encourage clinical efforts to target this pathway of programmed cell death.
Insights
Necroptosis, a programmed cell death pathway, significantly contributes to fibrosis development. Inhibitors targeting necroptosis show promise in treating fibrotic diseases, highlighting its therapeutic potential.
Area of Science:
- Cell Biology
- Pathophysiology
- Molecular Mechanisms
Background:
- Necroptosis is a distinct form of programmed cell death.
- Necroptosis plays a role in various diseases like liver disease, renal injury, and cancer.
- Fibrosis is a common pathological outcome of chronic inflammatory disorders.
Purpose of the Study:
- To review the impact of necroptosis on fibrosis.
- To discuss necroptosis inhibitors and their application in fibrosis models.
- To clarify necroptosis's role in fibrosis and encourage clinical targeting.
Main Methods:
- Literature review of necroptosis and fibrosis.
- Analysis of necroptosis's contribution to fibrotic processes.
- Examination of necroptosis inhibitors in preclinical fibrosis models.
Main Results:
- Necroptosis is a contributing factor in the development of fibrosis.
- Necroptosis inhibitors have been investigated in fibrosis models.
- Evidence supports necroptosis's role in the pathophysiology of fibrotic diseases.
Conclusions:
- Necroptosis is a key player in fibrosis.
- Targeting necroptosis pathways offers a potential therapeutic strategy for fibrotic diseases.
- Further clinical research is warranted to explore necroptosis inhibitors for fibrosis treatment.
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