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Updated: Jul 12, 2025
08:55
Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
Published on: August 7, 2018
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Targeting necroptosis in fibrosis
Emad H M Hassanein1, Islam M Ibrahim2, Mostafa S Abd El-Maksoud2
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt. emadhassanien@azhar.edu.eg.
Molecular Biology Reports
|November 1, 2023
Summary
Necroptosis, a programmed cell death pathway, significantly contributes to fibrosis development. Inhibitors targeting necroptosis show promise in treating fibrotic diseases, highlighting its therapeutic potential.
Area of Science:
- Cell Biology
- Pathophysiology
- Molecular Mechanisms
Background:
- Necroptosis is a distinct form of programmed cell death.
- Necroptosis plays a role in various diseases like liver disease, renal injury, and cancer.
- Fibrosis is a common pathological outcome of chronic inflammatory disorders.
Purpose of the Study:
- To review the impact of necroptosis on fibrosis.
- To discuss necroptosis inhibitors and their application in fibrosis models.
- To clarify necroptosis's role in fibrosis and encourage clinical targeting.
Main Methods:
- Literature review of necroptosis and fibrosis.
- Analysis of necroptosis's contribution to fibrotic processes.
- Examination of necroptosis inhibitors in preclinical fibrosis models.
Main Results:
- Necroptosis is a contributing factor in the development of fibrosis.
- Necroptosis inhibitors have been investigated in fibrosis models.
- Evidence supports necroptosis's role in the pathophysiology of fibrotic diseases.
Conclusions:
- Necroptosis is a key player in fibrosis.
- Targeting necroptosis pathways offers a potential therapeutic strategy for fibrotic diseases.
- Further clinical research is warranted to explore necroptosis inhibitors for fibrosis treatment.
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