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The role of m6A RNA methylation regulator in meningioma

Yu Yang1,2, Liqin Luo2,3, Zhiwu Zhou2,4

  • 1Department of Neurosurgery, Jiangxi Provincial People’s Hospital, Nanchang 330006, Jiangxi, China.

Aging
|November 1, 2023
PubMed

Insights

N6-Methyladenosine (m6A) regulators METTL3 and IGF2BP2 are crucial in meningioma development. Lower expression of these m6A regulators indicates poorer survival, suggesting they are potential therapeutic targets for meningioma.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Meningiomas are common intracranial tumors with often unsatisfactory surgical outcomes.
  • N6-Methyladenosine (m6A) RNA methylation regulators are implicated in various cancers.
  • The specific roles of m6A regulators in meningioma pathogenesis remain largely unelucidated.

Purpose of the Study:

  • To investigate the involvement of m6A RNA methylation regulators in meningioma.
  • To identify potential prognostic biomarkers and therapeutic targets for meningioma.

Main Methods:

  • Bioinformatic analysis including Cox regression and weighted gene co-expression network analysis.
  • Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.
  • In vitro experiments to validate gene expression levels in meningioma cells.

Main Results:

  • METTL3 and IGF2BP2 were identified as key m6A regulators associated with patient survival.
  • A novel methylation signature (RiskScore) was developed for prognostic prediction.
  • Lower mRNA and protein expression of METTL3 and IGF2BP2 were observed in meningioma cells compared to normal cells.

Conclusions:

  • METTL3 and IGF2BP2 play significant roles in meningioma and could serve as novel therapeutic targets.
  • The developed RiskScore methylation signature shows potential for prognostic prediction in meningioma patients.
Keywords:
m6A methylationmeningiomasoverall survival (OS)risk score

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