The use of tryptophan in normal-weight bulimia

Animal studies have implicated serotonin in the regulation of eating behavior. Hypothalamic serotonin receptor sites have been postulated to explain the inhibitory effect of serotonin on feeding behavior. This case study reports on the successful diminution of bingeing behavior in a normal weight bulimic female who was administered oral tryptophan, a serotonin precursor. The patient received a six week trial of tryptophan at a daily dosage of 20 mg/kg. A cessation of both the urge to binge and the behavior itself was noted. These preliminary findings are consistent with animal models suggesting the regulation of satiety is dependent on the inhibitory action of serotonin. Implications for the treatment of bulimic individuals are discussed.