Common cytogenetic findings in gastric cancer

Cytogenetic analysis was performed in five cases of intestinal type gastric carcinoma. Three cases were near-diploid and two others were near-triploid. The chromosomes involved were: #9 (four cases), #8 (three cases), #1, and #7 (two cases each). The nonrandom chromosomal abnormalities included aberrations of chromosome #9 as trisomy or i(9q) or 9p+ marker chromosome and excess of 8q material (i.e., trisomy or i(8q) chromosome). Our results indicate that abnormalities of chromosome #9 are a common feature in a subgroup of intestinal type gastric cancers and that there are common cytogenetic abnormalities in gastric and large bowel cancer.