Related Experiment Videos
Phase I study of iproplatin in pediatric patients: a Pediatric Oncology Group Study
Cancer Treatment Reports
|January 1, 1987
Abstract:
Iproplatin was evaluated in a phase I study in children to determine the maximum tolerated dosage. The dose-limiting toxic effect was found to be myelosuppression, which in part was related to the amount of prior therapy with irradiation and other anticancer agents. The dosage recommended for phase II trials in children is 324 mg/m2 iv over 2 hours every 3-4 weeks.